Query Within Query - Checking For Multiple Fields

Hi,
I remember seeing a fancy query that checked for multiple fields in a table (I think using a select statement in the where clause but not sure), but can't remember how to do it... here is what I want to do (and maybe there is a much easier way). Thanks!

Table1
id item color
1 shoe red
2 shoe blue
3 coat green
4 coat black

Table2
item color
shoe red
coat green

I want everything in Table1 where item and color are not a match.

So my results should be:
2 shoe blue
4 coat black

I'm sorry if this is a dumb question... it's been that kind of a day!

Thanks!