Random Timeout Expired When Creating Connection

I have an ASP.Net 2.0 app that is using sql express. Every couple days I get a "Timeout Expired" error message when creating a connection (not when running a query). This never happens on dev machine, just on production server. I am using a named instance of sqlexpress, sample connection string: "Data Source=.sqlexpress;Database=MyDBName;Trusted_Connection=true;". This is all running on Win2K3 server under NETWORK SERVICE account. Any ideas?

Stack trace follows:[SqlException (0x80131904): Timeout expired.  The timeout period elapsed prior to completion of the operation or the server is not responding.]
   System.Data.SqlClient.SqlInternalConnection.OnError(SqlException exception, Boolean breakConnection) +734867
   System.Data.SqlClient.TdsParser.ThrowExceptionAndWarning(TdsParserStateObject stateObj) +188
   System.Data.SqlClient.TdsParserStateObject.ReadSniError(TdsParserStateObject stateObj, UInt32 error) +556
   System.Data.SqlClient.TdsParserStateObject.ReadSni(DbAsyncResult asyncResult, TdsParserStateObject stateObj) +164
   System.Data.SqlClient.TdsParserStateObject.ReadPacket(Int32 bytesExpected) +34
   System.Data.SqlClient.TdsParserStateObject.ReadBuffer() +30
   System.Data.SqlClient.TdsParserStateObject.ReadByte() +17
   System.Data.SqlClient.TdsParser.Run(RunBehavior runBehavior, SqlCommand cmdHandler, SqlDataReader dataStream, BulkCopySimpleResultSet bulkCopyHandler, TdsParserStateObject stateObj) +59
   System.Data.SqlClient.SqlInternalConnectionTds.CompleteLogin(Boolean enlistOK) +33
   System.Data.SqlClient.SqlInternalConnectionTds.OpenLoginEnlist(SqlConnection owningObject, SqlConnectionString connectionOptions, String newPassword, Boolean redirectedUserInstance) +628
   System.Data.SqlClient.SqlInternalConnectionTds..ctor(DbConnectionPoolIdentity identity, SqlConnectionString connectionOptions, Object providerInfo, String newPassword, SqlConnection owningObject, Boolean redirectedUserInstance) +170
   System.Data.SqlClient.SqlConnectionFactory.CreateConnection(DbConnectionOptions options, Object poolGroupProviderInfo, DbConnectionPool pool, DbConnection owningConnection) +359
   System.Data.ProviderBase.DbConnectionFactory.CreatePooledConnection(DbConnection owningConnection, DbConnectionPool pool, DbConnectionOptions options) +28
   System.Data.ProviderBase.DbConnectionPool.CreateObject(DbConnection owningObject) +424
   System.Data.ProviderBase.DbConnectionPool.UserCreateRequest(DbConnection owningObject) +66
   System.Data.ProviderBase.DbConnectionPool.GetConnection(DbConnection owningObject) +496
   System.Data.ProviderBase.DbConnectionFactory.GetConnection(DbConnection owningConnection) +82
   System.Data.ProviderBase.DbConnectionClosed.OpenConnection(DbConnection outerConnection, DbConnectionFactory connectionFactory) +105
   System.Data.SqlClient.SqlConnection.Open() +111