SQL 2012 :: Execution Plan With Many Similar Missing Index Messages?

I'm in the process of trying to optimize a stored procedure with many queries. The execution plan provides a missing non-clustered index on nearly every query, and they're all fairly similar. The only real difference between them are what's in the INCLUDE statement. The two key columns are listed in every missing index. Let's say each query is approximately 5% of the total batch and 90% of the queries all fall into the category I listed above. How should I go about creating the missing indexes? Create all of the missing indexes or create one generic one that has all the INCLUDE columns? Create a minimal index with just a few of the common INCLUDE columns?

Here's an example of what I'm talking about with the missing indexes:

/*
USE [DB]
GO
CREATE NONCLUSTERED INDEX [<Name of Missing Index, sysname,>]
ON [dbo].[TABLE_1] ([COLUMN_A],[COLUMN_B])
INCLUDE ([C4ABCD],[C4ARTX],[C4ASTX],[C4ADNB],[C4AFNB],[C4BKVA])
GO
*/
/*

The Query Processor estimates that implementing the following index could improve the query cost by 99.9044%.

*/
/*
USE [DB]
GO
CREATE NONCLUSTERED INDEX [<Name of Missing Index, sysname,>]
ON [dbo].[TABLE_1] ([COLUMN_A],[COLUMN_B])
INCLUDE ([C4ARTX],[C4ASTX],[C4ADNB],[C4CZST])
GO
*/

/*

The Query Processor estimates that implementing the following index could improve the query cost by 99.5418%.

*/
/*
USE [DB]
GO
CREATE NONCLUSTERED INDEX [<Name of Missing Index, sysname,>]
ON [dbo].[TABLE_1] ([COLUMN_A],[COLUMN_B])
INCLUDE ([C4ABCD],[C4ARTX],[C4ASTX],[C4ADNB],[C4AFNB],[C4BKVA])
GO
*/