SQL Server Admin 2014 :: Indexes With More Writes Than Reads

I have inherited a database that is over-indexed, i.e. there are sometimes 10-20 indexes on a table. The performance is at times not great due to blocking from long running queries. I want to clean up the indexes as a starting point.

Through a query I found some time ago on the SQLCat blog I have discovered a large number of indexes in the database that have a huge disparity between reads and writes. The range of difference is sometimes almost 2 million more writes than reads. Should I just drop the indexes that have say, more than 100,000 more writes than reads and then see what the Missing Index DMVs tell me after a few days of running without those indexes?

In some cases there are a few hundred thousand reads but maybe a million writes on the index. Thus, there are a fair number of reads happening, just not in comparison to the number of writes. In some cases there are almost no reads and a million or more writes. I am obviously dropping those indexes. I just am not sure what to do about the indexes that do have a fair number of reads.