Transact SQL :: Update Same Row Multiple Times

I am trying to update the same row of the table multiple times. in other words, i am trying to replace the two stings on same row with two different values.

Example: if the column has a string "b" then replace with "B" and  if the column has a string "d" then replace with "D" . I can  write multiple updates to update it but i was just wondering if it can be done with single UPDATE statement

column before the update : bcdxyz
after the update: BcDxyz

Following is the sample data

declare @t1 table
(
    c1 varchar(5),
    c2 varchar(10),
    c3 varchar(5)
)
insert into @t1 values ('a','bcdxyz','efg')

[Code] ....