Play Buttons Not Working - Audio Dropping Out And Sounding Robotic

So I've used Windows 10 for about 6 months now without any issues beyond a game or two not working, which usually have obvious solutions or unofficial patches. This one stumped me though.

Basically, all play buttons stop working randomly, as well as audio dropping out and sounding robotic, as if slowed down significantly, upon returning.

Some background, this issue began a few days ago, after my third monitor broke. I won't go into that, as it shouldn't matter, but after it broke and I unplugged it, the issues began to arise. I was attempting to edit something in Premiere Pro when I noticed it first. The preview window would not play, although the play icon would turn into a stop icon. I didn't think much of this, but decided to test something else by making a new project and putting some other footage in. This worked. I assumed that the issue was with my SD card, as the other footage was gameplay recorded directly from the PC, whereas the other footage was taken from my camera. I rebooted, and the issue was gone... for a bit. A little bit later, the same issue occurred. This time, however, no footage whatsoever would work. Even YouTube wouldn't work. The only software that could play video was VLC. I did have this issue before, I believe sometime in November. That time a reboot fixed the issue for months.

Later I began to notice other issues. Audio would drop out for a few seconds, no matter what was playing. Spotify, YouTube, Premiere, everything. Sometimes it would come back normally. I've checked my interface, and it appears to be fine (it's a Focusrite Scarlett 2i2). Sometimes audio comes back robotic, like it was slowed down by editing or by using the speed option in YouTube. I've never had this issue with Windows 7.

I've reset to a slightly earlier build of Windows, but it hasn't worked. Since I've had 10 for more than a month I cannot revert to 7 without a clean install, which I'm hoping not to do, mainly because a clean install would obviously be terrible since I'll have to reinstall everything, but also because I do like Windows 10, and have had no issues so far.